Marco W Fraaije

Latest

• Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases
• Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering
• Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
• Exploring the Biocatalytic Potential of a Self‐Sufficient Cytochrome P450 from Thermothelomyces thermophila
• Stabilization of cyclohexanone monooxygenase by computational and experimental library design
• Side-chain pruning has limited impact on substrate preference in a promiscuous enzyme
• Exploring the substrate scope of Baeyer–Villiger monooxygenases with branched lactones as entry towards polyesters
• Experimental protocols for generating focused mutant libraries and screening for thermostable proteins
• Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution
• Polycyclic ketone monooxygenase (PockeMO): A robust biocatalyst for the synthesis of optically active sulfoxides
• Overriding traditional electronic effects in biocatalytic Baeyer–Villiger reactions by directed evolution
• Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila: A Structurally Distinct Biocatalyst for Bulky Substrates