Computational Biology

Curse and Blessing of Non-proteinogenic Parts in Computational Enzyme Engineering
Enzyme engineering aims to improve or install a new function in biocatalysts for applications ranging from chemical synthesis to …
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Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution
Baeyer–Villiger monooxygenases (BVMOs) and evolved mutants have been shown to be excellent biocatalysts in many stereoselective …
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A computational library design protocol for rapid improvement of protein stability: FRESCO
The ability to stabilize enzymes and other proteins has wide-ranging applications. Most protocols for enhancing enzyme stability …
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Overriding traditional electronic effects in biocatalytic Baeyer–Villiger reactions by directed evolution
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor public reputation, despite their …
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