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Directed Evolution
High-Throughput Engineering
Using cutting-edge screening technologies to sample vast numbers of (designed) protein variants.
Interdisciplinary Protein Design
The best of both worlds - design proteins on the computer
and
engineer them in the lab.
Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution
Baeyer–Villiger monooxygenases (BVMOs) and evolved mutants have been shown to be excellent biocatalysts in many stereoselective …
Guangyue Li
,
Maximilian JLJ Fürst
,
Hamid Reza Mansouri
,
Anna K Ressmann
,
Adriana Ilie
,
Florian Rudroff
,
Marko D Mihovilovic
,
Marco W Fraaije
,
Manfred T Reetz
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DOI
Overriding traditional electronic effects in biocatalytic Baeyer–Villiger reactions by directed evolution
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor public reputation, despite their …
Guangyue Li
,
Marc Garcia-Borràs
,
Maximilian JLJ Fürst
,
Adriana Ilie
,
Marco W Fraaije
,
KN Houk
,
Manfred T Reetz
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DOI
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