Review

Curse and Blessing of Non-proteinogenic Parts in Computational Enzyme Engineering
Enzyme engineering aims to improve or install a new function in biocatalysts for applications ranging from chemical synthesis to …
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The Expanded Central Dogma: Genome Resynthesis, Orthogonal Biosystems, Synthetic Genetics
Synthetic biology seeks to probe fundamental aspects of biological form and function by construction [i.e., (re)synthesis] rather than …
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New chemistries and enzymes for synthetic genetics
Beyond the natural nucleic acids DNA and RNA, nucleic acid chemistry has unlocked a whole universe of modifications to their canonical …
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Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases
Monooxygenases (MOs) face the challenging reaction of an organic target, oxygen and a cofactor – most commonly heme or flavin. To …
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Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical industry a poor public reputation, despite their …
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Side-chain pruning has limited impact on substrate preference in a promiscuous enzyme
Detoxifying enzymes such as flavin-containing monooxygenases deal with a huge array of highly diverse xenobiotics and toxic compounds. …
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